Fain's Honey was established in 1926 by H.E. Fain. Having been raised on a farm near Killeen, Texas, he as many other in that area, began his life as a farmer. In 1926 a very young H.E. Fain worked on the farm all year, and after the crops were gathered and sold, he ended the year with a net profit of only $130. During that year, he had accumulated around 10 hives of bees to which he had paid little attention up to this point.

Desperate, he robbed the bees late that summer and sold the honey on the Gatesville, Texas town square. Surprisingly, he ended up making close to $200 from the honey sales. Beekeeping appeared to be much less frustrating and certainly more lucrative than farming, so Fain quit farming and began cutting bee trees, collecting both the honey and the bees. For nine years he continued with beekeeping, increasing his number of colonies to 175.

Mr. H.E. Fain passed away in 1968, and Dewey Fain, the youngest of four sons, who had been working with him all his life, took over. Over the years since Dewey owned Fain's Honey his wife, Erwinna, helped with many aspects of the business as well as their three children, Kristi, Kevin, and Keith.

As of April 2005, Dewey's youngest son, Keith acquired the business from his dad and has expanded the product line even further to include a wider variety of honey spreads, ribbon cane syrup, and sorghum molasses. Keith is the 3rd generation Fain to own Fain's Honey.